Actualités
Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer | BioRxiv
Cancer cells are highly plastic, allowing them to adapt to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved...
Axon guidance during mouse central nervous system regeneration is required for specific brain innervation | Developmental Cell
Reconstructing functional neuronal circuits is one major challenge of central nervous system repair. Through activation of pro-growth signaling pathways, some neurons achieve long-distance axon regrowth. Yet, functional reconnection has hardly been obtained...
scConfluence: single-cell diagonal integration with regularized Inverse Optimal Transport on weakly connected features | Nature Communications
The abundance of unpaired multimodal single-cell data has motivated a growing body of research into the development of diagonal integration methods. However, the state-of-the-art suffers from the loss of biological information due to feature conversion and struggles with modality-specific populations...