We are seeking a motivated, independent postdoctoral researcherto study lineage progression and mechanisms guiding neural diversification during human nervous system development.

The project will leverage organoid models developed by our lab (Gribaudo et al, Nature biotechnology, 2024, Maury et al, Nature biotechnology, 2015; Mouilleau et al, Development, 2021; Duval et al, Development, 2019) and embryonic tissues coupled to bulk and single-cell omics data to explore how signaling pathways control genetic networks underlying cell fate decisions and the evolution of neuronal diversity in the human hindbrain and spinal cord.

Expected profile:

• Strong interest in developmental biology
• Demonstrated experience in single-cell RNA sequencing together with downstream bioinformatic analyses.
• Prior experience with genomic approaches in particular Chip-seq, ATAC-seq, Cut&tag will be an important asset.
• Experience with iPSC culture and differentiation will be highly valued but is not mandatory. Direct technical support for cell culture including organoid differentiation will be provided.
• A competitive track record
• Ability to work both autonomously and in collaboration, excellent team spirit
• Good communication skills, fluency in spoken and written English.

Environment

• The Institut Jacques Monod is located in central Paris, is a leading international center with a rich collaborative culture offering a vibrant highly interactive scientific environment and access to cutting-edge core facilities.
• Our team offers an exciting research environment at the intersection of neurodevelopment, cell biology and genomics. Our team employs a broad range of techniques—including work with organoids, embryonic tissues omics approaches, advanced imaging—to explore principles of cell fate specification and tissue morphogenesis. We have recently moved into a newly renovated laboratory space with brand-new culture rooms dedicated to organoid research with state-of-the-art equipment. English is the working languagefor lab meetings, seminars, and daily communication.

Professional Development & Support

• The position is fully funded but we will also provide support for competitive fellowship applications (EMBO, HFSP, etc.)
• We are part of the Cell ID (Cellular Identities and Destinies) program, a network of laboratories with complementary and synergistic expertise dedicated to studying cell trajectories during development. The program provides postdoctoral researchers with access to meetings, seminars, specialized training programs and competitive funding for research projects.

Application Process

• Interested candidates should send a CV, a cover letter detailing their research interest, and contact information for two to three references to: stephane.nedelec@inserm.fr

• Applications will be considered on a rolling basis until the position is filled. Learn more on : https://www.ijm.fr/research-topics/ribes-nedelec-lab-va/?lang=en